Antiviral drugs and interferon

the molecular basis of their activity

Publisher: M. Nijhoff in Boston

Written in English
Cover of: Antiviral drugs and interferon |
Published: Pages: 446 Downloads: 101
Share This

Subjects:

  • Antiviral agents,
  • Interferon,
  • Herpes simplex virus -- Effect of drugs on,
  • Viruses -- Reproduction,
  • Antiviral agents,
  • Interferons,
  • Virus diseases -- Drug therapy,
  • Virus replication -- Drug effects

Edition Notes

Includes bibliographies and index.

Statementedited by Yechiel Becker.
SeriesDevelopments in molecular virology ;, 4
ContributionsBecker, Yechiel.
Classifications
LC ClassificationsRM411 .A575 1984
The Physical Object
Paginationxv, 446 p. :
Number of Pages446
ID Numbers
Open LibraryOL2842133M
ISBN 100898386438
LC Control Number84004045

Antiviral drugs. For many years, a combination of two antiviral drugs were used to treat hepatitis C. Antiviral drugs are medications designed to rid the body of viruses. Interferon beta-1a, currently in use to treat multiple sclerosis, and interferon alfa-2b are both under investigation as potential treatments for people with COVID coronavirus disease, the deadly respiratory pandemic caused by the SARS-nCoV-2 virus.. Essentially, when confronted with a virus, each cell shoots an emergency flare of interferon to tell the immune system to . The purpose of the series, Advances in Antiviral Drug Design, is to regularly provide an account on the chemistry of the new antiviral agents (whether licensed or en route of licensing), and to discuss their structure-activity relationship, width of activity spectrum, and mechanism of action. The drug, called Interferon Alpha-2B Recombinant (IFNrec), is jointly developed by scientists from Cuba and China, where the coronavirus COVID .

New drug regimens, with or without interferon alfa-2b, last 12 or 24 weeks for people infected with the type of hepatitis C virus most common in North America and Europe. Until new antiviral drugs became available, treatment often had to last as long as 48 weeks. Antiviral drugs are a class of medication used specifically for treating viral infections. Like antibiotics for bacteria, specific antivirals are used for specific most antibiotics, antiviral drugs do not destroy their target pathogen; instead they inhibit their development.. Antiviral drugs are one class of antimicrobials, a larger group which also includes antibiotic . Antiviral medications may help reduce the symptoms of influenza. They must be taken within two days of the start of symptoms to be effective. In June , the World Health Organization removed one antiviral, oseltamivir (Tamiflu), from its list of e.   Christoph Höner zu Siederdissen, Benjamin Maasoumy, Fiona Marra, Katja Deterding, Kerstin Port, Michael P. Manns, Markus Cornberg, David Back, Heiner Wedemeyer, Drug–Drug Interactions With Novel All Oral Interferon-Free Antiviral Agents in a Large Real-World Cohort, Clinical Infectious Diseases, Vol Issue 5, 1 March , Pages Cited by:

The Jamaican Government says it will not be using the Cuban antiviral drug Interferon Alpha 2B to treat persons battling COVID The disease has killed five persons, with another testing positive. This development comes even as Washington blocked a supply of test kits destined for Jamaica, Health and Wellness Minister Dr Christopher. This book captures the state of the science with twenty reviews that examine the latest in today’s antiviral drug discovery efforts. The introduction of nucleoside analogs and investigations of novel antiviral targets have brought significant new possibilities to the field. These reviews range from in-depth analyses of a specific viral target, to examination of multiple targets in medically.   "Interferons are naturally occurring proteins, produced in response to viral infection, and the hope is that interferon beta-1b will boost the body's ability to fight SARS-CoV Future phase 3 trials will soon confirm or refute the usefulness of this candidate drug as a backbone treatment for COVID" [1]. True or False: Interferon is commonly used for veterinary antiviral treatment in the United States. False. Interferons are licensed for use in the treatment of viral disease of dogs and cats in Japan and other countries.

Antiviral drugs and interferon Download PDF EPUB FB2

Antiviral Drugs and Interferon: The Molecular Basis of Their Activity (Developments in Molecular Virology) [Yechiel Becker] on *FREE* shipping on qualifying offers. Research on antiviral drugs and their mode of action in infected cells.

in animals and in man. has led to a better understanding of the Antiviral drugs and interferon book pro­ cesses involved in virus replication. Research on antiviral drugs and their mode of action in infected cells. in animals and in man. has led to a better understanding of the molecular pro­ cesses involved in virus replication.

Screeninq of large numbers of natural and semisynthetic compounds resulted. The molecular basis of the antiviral activity of new and known drugs and their possible use in chemotherapy of viral disease are presented in this book. Keywords animals antibiotic cells enzymes interferon metabolism molecular basis molecule polymer protein proteins synthesis therapy toxicity virus.

This book focuses on new small molecule approaches to combat viral infections. The chapters describe the discovery and development from bench through the clinic of relatively recently-approved antiviral drugs and compounds in advanced clinical development. Organized by a virus (such as HIV, HCV, RSV, influenza.

Antiviral Drugs. The articles that appear in Antiviral Drugs - Aspects of Clinical Use and Recent Advances cover several topics that reflect the varied mechanisms of viral disease pathogenesis and treatment.

Clinical management and new developments in the treatment of virus-related Antiviral drugs and interferon book are the two main sections of the by: 6. Synthetic interferons, made by recombinant DNA technology, are used as antiviral agents to treat infections such as hepatitis and herpes zoster virus.

Interferons induce the production of enzymes in the ribosomes of the host cells and inhibit the translation of viral mRNA into viral proteins, therefore stop viral reproduction. Antiviral Drugs PDF – Aspects of Clinical Use and Recent Advances Antiviral Drugs PDF Free Download, Antiviral Drugs PDF, Antiviral Drugs Ebook Content The articles that appear in Antiviral Drugs – Aspects of Clinical Use and Recent Advances cover several topics that reflect the varied mechanisms of viral disease pathogenesis and treatment.

Antiviral drug, any agent used in the treatment of an infectious disease caused by a virus. Antiviral agents generally are designed to block viral replication or disable viral proteins. Examples of antiviral drugs include agents to combat herpes viruses, influenza viruses, and HIV.

The drugs equip the body to tackle viruses, preventing them from multiplying in the body. Interferon drugs first emerged for cancer therapy.

Interferons have also been used in the treatment of HIV and AIDS. Cuba manufactured its first interferon in and was used in the treatment of the haemorrhagic dengue epidemic in Cuba the same year. Flu Spotlight: CDC Research Confirms Benefits of Flu Antiviral Drugs, Even Beyond 2 Days After Symptoms Start Novem Have You Heard: CDC Influenza Antiviral Statement February 7, FDA Drug Safety Communication: Important safety changes to the influenza drug Tamiflu (oseltamivir phosphate) for oral suspension.

INTERFERON GENES AND PROTEINS. IFNs are a multigene family of inducible cytokines (40, 91, ).They possess antiviral activity (,).Indeed, the biological activity of IFN is most commonly assayed by determining the antiviral activity in cell culture, although radioimmunoassays and enzyme-based immunoassays are also available for Cited by: Antiviral Drug Discovery gives readers a cutting-edge view of how chemical concepts are being mobilized to develop novel approaches that will effectively confront emerging diseases and biowarfare.

Among the many topics discussed are smallpox, the Ebola virus, influenza, SARS, arenaviruses and : Paul F. Torrence. Antiviral drugs for seasonal influenza Med Lett Drugs Ther ; 59 (): PubMed Citation (Concise summary of safety and efficacy of medications for influenza appropriate for the season; discusses side effects of oseltamivir and zanamivir, but does not mention ALT elevations or hepatotoxicity).

A two-week course of antiviral therapy with interferon beta-1b plus lopinavir-ritonavir and ribavirin, started within 7 days of showing COVID symptoms, is safe and more effective at reducing. Alpha and beta interferon are considered type I interferons which share antiviral, immunomodulatory as well as antiproliferative effects.

The pathways of induction and actions of alpha interferon are quite complex and the antiviral effects are due to induction of multiple intracellular genes. Rosa Miriam Elizalde is a Cuban journalist and editor of the site Cubadebate.

Reprinted from La Jornada, translation by Resumen Latinoamericano, North America bureau. Cuba’s antiviral Recombinant Interferon Alpha 2B (IFNrec) is among the medicines chosen by China to treat the coronavirus, the disease that has already caused at least 1, deaths in that country.

• Possess antiviral, immunomodulatory and antiproliferative effects • Types – Alpha/Beta (leukocyte/fibroblast) • Coding genes located on chromosome 9 • At least 24 subtypes of alpha, 1 of beta – Gamma • Coding gene located on chromosome 12 • 1 subtype Interferons II: Mechanism of Action • Act by inducing an antiviral state File Size: KB.

Effective antiviral agents are needed to treat severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infection. We assessed the antiviral potential of recombinant interferons against two clinical isolates of SARS-CoV—FFM-1, from Frankfurt patients, and Hong Kong—replicated in Vero and Caco2 cells.

Interferon β was five to ten Cited by: The interferons can act on infected cells or neighboring cells to induce the expression of hundreds of interferon‐stimulated genes (ISGs) that aim to control or protect cells from viral infection. Infection of hepatocytes with hepatitis C virus (HCV) induces an interferon response and the expression of ISGs; however, many of the ISGs Author: Edmund Tse, Michael R.

Beard. Certain antiviral cytokines called type-1 interferons have been produced by recombinant DNA technology and several are used to treat certain severe viral infections. These include: recombinant interferon alfa-2a (Roferon-A): a cytokine used to treat Kaposi's sarcoma, chronic myelogenous leukemia, and hairy cell leukemia.

Chapters cover such topics as virus entry inhibitors, interferon-free drug combinations, and antiviral agents for HSV. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike.

This review of the publications on antiviral drugs covers drugs that are active against cytomegalovirus (cidofovir, foscarnet, ganciclovir, and valganciclovir), drugs that are active against herpesviruses (aciclovir, famciclovir, and valaciclovir), drugs that are active against hepatitis viruses (adefovir and ribavirin).

Since then, the Chinese Government got into action to combat the spread and care for those infected. Among the 30 medicines the Chinese National Health Commission selected to fight the virus was a Cuban anti-viral drug Interferon Alpha 2b.

Cuban Interferon Alpha 2b has proven effective for viruses with characteristics similar to those of COVID The book opens with a chapter that comprehensively reviews the antiviral effects of extracellular double-stranded RNA, the viral toxin. This is followed by chapters that review the properties of type I and type III interferons, and the role of interferon-stimulated genes.

The next five chapters are devoted to understanding the diverse strategies used by clinically relevant human viruses. A collection of 19 antiviral drugs was tested in the SARS-CoV CPE inhibition assay (Table 2).

The set of drugs tested included seven interferons, five nucleoside analogs, three protease inhibitors, two RT inhibitors, and two neuraminidase inhibitors. Complete inhibition of the CPE was observed for four of the seven interferons in the initial.

Most antiviral drugs have one target. Some antiviral drugs have broad-spectrum of activity. One of the primary differences between antibacterial and antiviral drugs is how they act toward the target pathogen. For example, a great many antibacterial drugs are bactericidal – namely, that they actively seek out.

antiviral drugs are recommended for both treatment and prevention of flu. antiviral drugs work best when taken within 48 hours of onset of flu symptoms.

This new volume of Advances in Pharmacology explores the current state of antiviral agents. Chapters cover such topics as virus entry inhibitors, interferon-free drug combinations, and antiviral agents for HSV.

With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists /5(9). A Drug Cocktail Hastens Recovery in Some Coronavirus Patients.

A combination of three antiviral drugs, including interferon, seemed to speed recovery, researchers reported. A combination of three antiviral drugs, including interferon, seemed to speed recovery, researchers reported. A better understanding of the viral cycle of HCV, and the characterization of viral enzymes that are potential targets, has resulted in the development of new molecules, direct-acting antiviral drugs targeted against HCV, either specific of genotype 1 (NS3/NS4A protease inhibitors and NS5 polymerase inhibitors) or with a wider spectrum (NS5A or entry inhibitors), and nonspecific .ISBN: OCLC Number: Description: xv, pages: illustrations ; 25 cm.

Contents: Introduction: Current Trends in Research on Antiviral Drugs (a Review).- 1 Introduction: Current Trends in Research on Antiviral Drugs (a Review)  The Race To Create The Best Antiviral Drugs Researchers want to create a widely effective drug that targets viruses much in the same way that penicillin kills a wide range of bacteria.

Science.